5/1/2023 0 Comments Anemona kuhlman![]() ![]() Kuhlman SJ, O'Connor DH, Fox K, Svoboda K. Top-Down-Mediated Facilitation in the Visual Cortex Is Gated by Subcortical Neuromodulation. J Neurosci. Pafundo DE, Nicholas MA, Zhang R, Kuhlman SJ. I use a range of techniques, including electrophysiological recordings of targeted cell types in-vivo and in-vitro, 2-photon microscopy, behavioral methods, and computational analyses. The specific goal of my research is to understand the influence of cortical inhibitory circuits on sensory development and perceptual learning. By comparing and contrasting learning in the young versus adult, we hope to identify, and ultimately rescue, the essential aspects of circuit construction that are vulnerable to deprivation and disease. Construction must proceed correctly for further adult learning to occur. The process of circuit assembly itself is finalized during the transition from childhood to adolescence, and influenced by experience. ![]() ![]() How to build a circuit for learning in the first place? By splicing the DNA that codes for fluorescent proteins found in jellyfish and corals into the genome of mice, in combination with state-of-the-art multiphoton laser-scanning microscopy, we visualize and track the circuit changes that occur in the brains of awake behaving animals as they learn new skills. As adults we constantly face challenges in our environment and must adapt our brain circuits to deal with new situations. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |